In 1994, Efren Reyes took part in the US open 9 Ball Pool Championships which he won defeating Nick Varner in the final.
Around 1996 Efren Reyes was chosen along with Earl Strickland to play each other in a challenge match which was named 'The Color of Money' after the movie of that name which was in fact the follow-up movie to the original Paul Newman film: 'The Hustler'. Basically this challenge match which was held in Hong Kong was a race to 120 playing 9 ball pool and the winner was to take home a prize of $100,000. At the end of the match, Efren Reyes came out the winner by 120-117.
In 1999, Efren became world 9 ball pool Champion when he won the first WPA World 9 ball pool championships to be broadcast on television.
In 2001 in Tokyo Japan, Reyes joined almost 700 other players to take part in the International billiard tournament with a total purse of around $850,000. In the final, he defeated Niels Feijen 15 -7 earning $170,000 in the process.
Efren became World Pool League Champion in both 2001 and 2002.
In 2003 Efren was inducted into the Billiard Congress of America's Hall of Fame.
In 2004, Efren Reyes defeated Marlon Manalo becoming the first ever WPA World 8 Ball Champion. Also in 2004, Efren was the winner of the San Miguel Asian 9 Ball Pool Tour.
In the winter of 2005, Reyes succeeded in winning the IPT King of the Hill 8 Ball Shootout in which he managed to win $200,000.
In 2006, Efren Reyes teamed up with his compatriot: Francisco Bustamante to represent team Philippines and they succeeded in winning the inaugural World Cup of Pool in South Wales in the UK. Also in 2006 Efren succeeded in winning the IPT World Open 8 Ball Championship defeating Rodney Morris 8-6 in the final.